Pilotless possibility... doubtful  

Nothing new under the sun.  Drones been flying since before WW2.  Still no passenger drones.

https://www.bbc.com/future/article/20231009-the-robot-aircraft-with-a-nightmarish-nuclear-mission

But, no crews could save airlines 35 billion/year:

https://www.forbes.com/sites/suzannerowankelleher/2023/02/26/pilotless-autonomous-self-flying-planes/?sh=1ececc8745ea

Eventually, enough human mistakes or a huge financial shift could force the airlines to go to one pilot, then no pilot.